IL10RA Antilichaam - N-terminaal gebied: Biotine (ARP45135_T100-Biotine)

Interleukin 10 receptor, alpha

CD210, IL10R, CD210a, CDW210A, HIL-10R, IL-10R1

3587

Q13651

NP_001549

Human, Rat, Cow, Dog, Guinea Pig, Horse

The immunogen is a synthetic peptide directed towards the N terminal region of human IL10RA

IL10RA is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

BTRC; UBC; IL10RB; JAK1; IL10

Biotin

Polyclonal Antibody

WB

0.5 mg/ml

Dog: 92%; Guinea Pig: 92%; Horse: 85%; Human: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

61kDa

Gasche, C., (2003) J. Immunol. 170 (11), 5578-5582

Wet Ice

578

IL10RA

IL10RA

Rabbit

Interleukin-10 receptor subunit alpha

NM_001558

GSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGN

Alpha