IL12RB1 Mouse Monoclonal Antibody [Kloon ID: LBI1A6]

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Carrier-free (BSA/glycerol-free) IL12RB1 mouse monoclonal antibody, clone LBI1A6

CD212; IL-12R-BETA1; IL12RB; IMD30

Homo sapiens interleukin 12 receptor subunit beta 1 (IL12RB1), transcript variant 2, mRNA.

3594

P42701

Unconjugated

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

WB 1:500

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

IL12RB1

https://www.ncbi.nlm.nih.gov/gene/?term=3594

https://www.uniprot.org/uniprot/P42701