IL15 Mouse Monoclonal Antibody [Kloon ID: LBI2B4]

The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x (L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]

Carrier-free (BSA/glycerol-free) IL15 mouse monoclonal antibody, clone LBI2B4

IL-15; Interleukin 15; MGC9721; OTTHUMP00000164617

Homo sapiens interleukin 15 (IL15), transcript variant 1

3600

P40933

Unconjugated

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

WB 1:500

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Secreted Protein

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

IL15

https://www.ncbi.nlm.nih.gov/gene/?term=3600

https://www.uniprot.org/uniprot/P40933