IL2 (NM 000586) Humaan Recombinant eiwit

This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020]

Purified recombinant protein of Human interleukin 2 (IL2), Tag free, secretory expressed in CHO cells, 100ug

IL-2; lymphokine; TCGF

3558

P60568, Q0GK43

NM_000586

4q27

CHO

Tag Free

Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus

Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus

>50 ug/mL as determined by microplate BCA method

< 1 EU per 1 µg of the protein by the LAL

> 95% as determined by SDS-PAGE and Coomassie blue staining

Lyophilized

Lyophilized from a sterile solution containing phosphate buffer, pH7.4.

Druggable Genome, Secreted Protein

15.4 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

IL2

Human

NP_000577

https://www.ncbi.nlm.nih.gov/gene/3558

https://www.uniprot.org/uniprot/P60568

https://www.ncbi.nlm.nih.gov/nuccore/NM_000586

https://www.ncbi.nlm.nih.gov/nuccore/NP_000577