IL7R Antilichaam - middelste regio : HRP (ARP59084 P050-HRP)

Interleukin 7 receptor

ILRA, CD127, IL7RA, CDW127, IL-7R-alpha

3575

P16871

NP_002176

Human, Dog, Horse

The immunogen is a synthetic peptide directed towards the middle region of human IL7R

The protein encoded by this gene is a receptor for interleukine 7 (IL7) . The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V (D) J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID) .

KIT; JAK3; SNRPG; SNRPD3; SNRPD2; SNRPD1; SNRPB; SNRPA; SNRNP70; SRSF3; SAFB; RPS20; RPS3; RPL31; RPL29; RPL30; RPL22; RPL18; RPL15; RPL8; RPL7; RPL6; RBM3; PURB; PURA; PTMA; PTBP1; EIF2AK2; YBX1; NONO; NCL; MAP4; RPSA; ILF3; ILF2; HNRNPU; HNRNPL; HNRNPH3

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Dog: 92%; Horse: 83%; Human: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

49kDa

Wet Ice

459

IL7R

IL7R

Rabbit

Interleukin-7 receptor subunit alpha

NM_002185

ESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCP

Alpha