Ilicicolin H

Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with KD of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection[1][2].

12689-26-8

12352005

H335

Apoptosis; Fungal; Phosphoglycerate Kinase (PGK)

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Cancer; Infection

O=C1C(C([C@H]2[C@H](/C=C/C)[C@@]3([H])C[C@@H](C)CC[C@]3([H])C(C)=C2)=O)=C(O)C(C4=CC=C(O)C=C4)=CN1

C27H31NO4

433.54

P261-P271-P304+P340-P403+P233-P405-P501

[1]Li M, et al. A novel inhibitor of PGK1 suppresses the aerobic glycolysis and proliferation of hepatocellular carcinoma. Biomed Pharmacother. 2023 Feb;158:114115.|[2]Singh SB, et al. Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. ACS Med Chem Lett. 2012 Sep 7;3 (10) :814-7.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N8540/

Natural Products

No Development Reported

PGK1