ILK (fosfo Ser246) Antilichaam

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

3611

Q13418

NP_001014794.1

Human, Mouse, Rat

ILK (phospho Ser246) antibody was raised against a peptide sequence around phosphorylation site of Serine 246 (I-F-S (p) -H-P) derived from Human ILK.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

51 kDa

IgG

The antibody detects endogenous levels of ILK only when phosphorylated at serine 246.

ILK

Integrin-linked kinase

Homo sapiens

Hannigan G.E., Nature 379:91-96 (1996) .

Janji B., Oncogene 19:3069-3077 (2000) .

Tadic B., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.

ILK1, p59ILK, kinase ILK

IHC

4758606

Liquid