ILP-2 Antilichaam

ILP-2 Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

112401

Q96P09

NP_203127

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis

ILP-2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1211 - HepG2 Cell Lysate

1 mg/mL

ILP-2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ILP-2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

33 kDa

IgG

BIRC8

Cat. No. 17-011 - Hep G2 Cell Slide

Baculoviral IAP repeat-containing 8

Homo sapiens

Richter BW, Mir SS, Eiben LJ, Lewis J, Reffey SB, Frattini A, Tian L, Frank S, Youle RJ, Nelson DL, Notarangelo LD, Vezzoni P, Fearnhead HO, Duckett CS. Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. Mol Cell Biol. 2001;21 (13) :4292-301.

ILP-2 Antibody: ILP2, ILP-2, hILP2, ILP2, Baculoviral IAP repeat-containing protein 8, Inhibitor of apoptosis-like protein 2, IAP-like protein 2

ELISA, WB, ICC, IF

44680139

Liquid