Iminostilbene-d10

Iminostilbene-d10 is the deuterium labeled Iminostilbene. Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases[1][2].

3044090-39-0

12352005

COX; HIF/HIF Prolyl-Hydroxylase; Interleukin Related; Isotope-Labeled Compounds; NO Synthase; Pyruvate Kinase; STAT; TNF Receptor

Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt

Inflammation/Immunology

[2H]C1=C(C2=C(NC3=C1C([2H])=C(C([2H])=C3[2H])[2H])C([2H])=C([2H])C([2H])=C2[2H])[2H]

C14HD10N

203.31

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W753956/

Isotope-Labeled Compounds

No Development Reported