IMPDH2 Antilichaam - C-terminaal gebied: Biotine (ARP54366_P050-Biotine)

IMP (inosine 5'-monophosphate) dehydrogenase 2

IMPD2, IMPDH-II

3615

P12268

NP_000875

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human IMPDH2

IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. It catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

RSG1; APIP; HUWE1; UBC; IMPDH2; CDK2; RPA1; RPA3; RPA2; PRKAR2A; IMPDH1; EIF2S3; PARK2; MAPK10; SOX2; NPM1; PEX14; FN1; RPLP0P6; RPS6; RPL15; FOLR1; FBXO6; GRB2; UBQLN4; PIAS4; COPS5; COPS6; CUL3; YWHAZ; FBXO25; SIRT7; HDAC5; MME; SUMO4; AKT1; IKBKE; ATG5

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 92%; Zebrafish: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

56kDa

Grinyo, J., (er) Transpl. Int. (2008) In press

Wet Ice

514

IMPDH2

IMPDH2

Rabbit

Inosine-5'-monophosphate dehydrogenase 2

NM_000884

SCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF