IMR-1
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Inhibitor of Mastermind Recruitment-1 (IMR-1) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription1. IC50=26 M (in vitro assay) . IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethylester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 M (in vitro assay) . Binding of IMR-1 to NTC is non-covalent and reversible.1
Unconjugated
Yellow solid
-20°C
Beschrijving
IMR-1 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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