Indole-3-carbinol (standaard)

Indole-3-carbinol (Standard) is the analytical standard of Indole-3-carbinol. This product is intended for research and analytical applications. Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1) .

700-06-1

12352100

H315, H319

Aryl Hydrocarbon Receptor; E1/E2/E3 Enzyme; Endogenous Metabolite; NF-κB; Reference Standards

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Cancer

98.31

OCC1=CNC2=C1C=CC=C2

C9H9NO

147.18

H315, H319

[1]Mohammadi S, et al. Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line.J Recept Signal Transduct Res. 2017 Oct;37 (5) :506-514.|[2]Safa M, et al. Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells. Tumour Biol. 2015 May;36 (5) :3919-30.|[3]Lee YR, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019 May 17;364 (6441) . pii: eaau0159.

Blue Ice

4°C, sealed storage, away from light and moisture

http://file.medchemexpress.com/batch_PDF/HY-N0170R/Indole-3-carbinol-Standard-SDS-MedChemExpress.pdf

Reference Standards

Phase 1