Indomethacinemethylester
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Indomethacin methylester (Compound 10; Indometacin methylester) is a potent and selective AKR1C3 inhibitor with an IC50 value of 5.67 μM. Indomethacin methylester is promising for research of postate cancer[1].
1601-18-9
Indometacin methylester
12352005
H302-H315-H319-H335
17β-HSD
Metabolic Enzyme/Protease
Cancer-programmed cell death
Cancer
O=C(CC1=C(C)N(C(C2=CC=C(C=C2)Cl)=O)C3=C1C=C(C=C3)OC)OC
C20H18ClNO4
371.81
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
[1]Liedtke AJ, et al. Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. J Med Chem. 2013 Mar 28;56 (6) :2429-46.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W024692/
Reference compound1
No Development Reported
Beschrijving
Indomethacin methylester (Compound 10; Indometacin methylester) is a potent and selective AKR1C3 inhibitor with an IC50 value of 5.67 μM. Indomethacin methylest
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