ING-1

ING-1 (heMab) is a high-affinity humanized monoclonal antibody against epithelial cell adhesion molecule (Ep-CAM) . ING-1 is a transmembrane glycoprotein mediating Ca2+. ING-1 binds to Ep-CAM on tumor cells and exhibits potent in vitro activity, targeting and inhibiting tumor growth and metastasis in mouse cancer models. ING-1 is useful in the research of breast, colorectal, and lung cancers, among other cancers[1][2].

HeMab

12352100

Transmembrane Glycoprotein

Immunology/Inflammation

Cancer

[1]Ammons WS, et al. In vitro and in vivo pharmacology and pharmacokinetics of a human engineered monoclonal antibody to epithelial cell adhesion molecule. Neoplasia. 2003 Mar-Apr;5 (2) :146-54.|[2]Ruan HH, et al. ING-1 (heMAb), a monoclonal antibody to epithelial cell adhesion molecule, inhibits tumor metastases in a murine cancer model. Neoplasia. 2003 Nov-Dec;5 (6) :489-94.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P991646/

Inhibitory Antibodies

No Development Reported