INHA Antilichaam [4A2]

INHA (A-inhibin subunit precursor, inhibin alpha subunit), also called inhibin (alpha), which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH) . Inhibin comprises of two subunits, Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal, bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.

3623

P05111

P05111

Human

Ni-NTA purified truncated recombinant INHA expressed in E. Coli strain BL21 (DE3) .

4A2

Unconjugated

Primary Antibodies

Growth Factors

Antibody is purified by protein A affinity chromatography.

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

INHA (Inhibin alpha) monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

INHA

Inhibin, alpha

Homo sapiens

Mayo, K.E., Cerelli, G.M., Spiess, J., et al. 1986. Proc. Natl. Acad. Sci. USA 83: 5849-5853.

GM LM, WF Crowley, Jr, AL Schneyer.1995.J. Clin. Endocrinol. Metab., Oct . 80:3043-3049.

Knight, P.G. 1996.Front. Neuroendocrinol. 17: 476-509.

PA Fahy, CA Wilson, AJ Beard, et al. 1995.J Endocrinol Nov.147:271-283.

Inhibin alpha chain

ELISA, WB, IHC

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