Inosine-5'-difosfaat (dinatrium)

Inosine-5'-diphosphate disodium (IDP disodium) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate disodium has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM) . Inosine-5'-diphosphate disodium abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate disodium has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate disodium can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research[1][2][3].

54735-61-4

IDP (disodium) ; Inosine-5'-diphosphoric acid (disodium)

12352005

H302, H315, H319, H335

Apoptosis; c-Myc

Apoptosis

Cancer-Kinase/protease

Cancer; Inflammation/Immunology; Cardiovascular Disease

99.08

H2O : 175 mg/mL (ultrasonic)

O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O3)C=N2)NC=N1

C10H14N4O11P2

428.19

H302, H315, H319, H335

[1]Sengupta P, et al. Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding. Biochim Biophys Acta Gen Subj. 2020 Sep;1864 (9) :129649. |[2]Sokolov I K, et al. Adaptogenic effect of riboxin[J]. Pharmaceutical Chemistry Journal, 1980, 14 (1) : 34-39.|[3]Veveris M, et al. Experimental study of the antiarrhythmic effect of riboxin. Farmakol. Neirotropnykh Sredstv (1978), 119-24.

Room Temperature

4°C (Powder, sealed storage, away from moisture and light)

http://file.medchemexpress.com/batch_PDF/HY-W013724/Inosine-5-diphosphate-disodium-SDS-MedChemExpress.pdf

Reference compound2

No Development Reported