Inosine-5'-trifosfaat (trinatriumzout) (standaard)

Inosine-5'-triphosphate (trisodium salt) (Standard) is the analytical standard of Inosine-5'-triphosphate (trisodium salt). This product is intended for research and analytical applications. Inosine-5'-triphosphate trisodium salt is a nucleotide analogue that acts on multiple G proteins and is widely used in G protein-related research. It can bind to the α -subunit of G proteins and participate in G protein-mediated signal transduction as a substitute for GTP. Its mechanism of action is to interact with the nucleotide-binding site of the G protein α -subunit, affecting the activity and function of G proteins. In the research field, it is mainly used to explore the role of the G protein signaling pathway in cellular physiological and pathological processes. For example, in HL-60 leukemia cells, its impact on G protein-mediated signal transduction can be studied[1][2][3][4].

35908-31-7

Endogenous Metabolite; Reference Standards

Metabolic Enzyme/Protease; Others

Metabolic Disease

O[C@@H]([C@H](N1C=NC2=C1NC=NC2=O)O3)[C@H](O)[C@H]3COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O

C10H12N4Na3O14P3

574.11

[1]Hanson RL, et al. Energy-transducing adenosine triphosphatase from Escherichia coli: purification, properties, and inhibition by antibody. J Bacteriol. 1973 May;114 (2) :772-81.|[2]Pieper U, et al. The GTP-binding domain of McrB: more than just a variation on a common theme? J Mol Biol. 1999 Sep 24;292 (3) :547-56.|[3]Klinker JF, et al. Functionally nonequivalent interactions of guanosine 5'-triphosphate, inosine 5'-triphosphate, and xanthosine 5'-triphosphate with the retinal G-protein, transducin, and with Gi-proteins in HL-60 leukemia cell membranes. Biochem Pharmacol. 1997 Sep 1;54 (5) :551-62.|[4]Burnstock G, et al. Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide. Br J Pharmacol. 1972 Mar;44 (3) :451-61.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W013706R/

Reference Standards