INPP4B Antilichaam

Inositol polyphosphate 4-phosphatase type II (INPP4B) is one of the enzymes involved in phosphatidylinositol signaling pathways. It removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate (1) . INPP4B can function as a tumor suppressor by inhibiting PI3K signaling. In human epithelial cells, knockdown of INPP4B expression resulted in enhanced Akt activation, anchorage-independent growth, and enhanced overall motility (2) . It is thought INPP4B may also have oncogenic functions as INPP4B-dependent PI3K signaling is mediated by SGK3 in breast cancer cells and expression of INPP4B leads to enhanced SGK3 activation and suppression of AKT phosphorylation (3) .

8821

Q9BS68

NP_003857

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

INPP4B antibody is affinity chromatography purified via peptide column.

Cat. No. 1282 - 3T3 (NIH) Cell Lysate

1 mg/mL

INPP4B antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

INPP4B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

INPP4B antibody is human, mouse and rat reactive. At least two isoforms of INPP4B are known to exist; this antibody only detects the longer isoform. INPP4B antibody is predicted to not cross-react with INPP4A.

INPP4B

Cat. No. 17-201 - 3T3/BALB Cell Slide

Inositol polyphosphate-4-phosphatase, type II, 105kDa

Homo sapiens

Norris FA, Auethavekiat V, and Majerus PW. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphase. J. Biol. Chem. 1995; 270:16128-33.

Gewinner C, Wang ZC, Richardson A, et al. Evidence that inositol polyphosphate 4-phosphase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 2009; 16:115-25.

Gasser JA, Inuzuka H, Lau AW, et al. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Mol. Cell 2014; 56:595-607.

Inositol polyphosphate-4-phosphatase type II 105kDa

ELISA, WB, ICC

156104895

Liquid