INPP5D Antilichaam - C-terminal regio : HRP (ARP61033 P050-HRP)

Inositol polyphosphate-5-phosphatase, 145kDa

SHIP, SHIP1, SHIP-1, hp51CN, SIP-145, p150Ship

3635

Q92835

NP_001017915

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5) -trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

NOTCH2NL; KRTAP10-3; KRTAP10-9; KRTAP10-7; KRT40; KHDRBS3; KRT31; DAB1; SH3KBP1; XIAP; INPPL1; LRRK1; SHC1; PTPN11; UBASH3B; CD2AP; SYK; NCK1; GRB2; CBL; UBC; ARAP1; BCR; CLYBL; MME; EPOR; TRIP10; CD300LF; DOK3; LILRB4; INPP5D; FCGR2B; GAB2; DOK2; GAB1; D

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 86%; Dog: 86%; Guinea Pig: 79%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 93%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

131kDa

Wet Ice

1189

INPP5D

INPP5D

Rabbit

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

NM_001017915

PPTPTPRPPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPL