INSIG1 Antilichaam - middengebied : HRP (ARP40162_P050-HRP)

Insulin induced gene 1

CL6

3638

A4D2M9

NP_938150

Human

The immunogen is a synthetic peptide directed towards the middle region of human INSIG1

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR) - and sterol regulatory element-binding protein (SREBP) -mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

UBC; HMGCR; FAF2; SCAP; ERLIN2; ERLIN1; VCP; AMFR; PGRMC1; POR; SREBF1; ELAVL1; RNF139; INSIG2; PSMC3; PSMA7; INSIG1; VAPA; VAPB; SREBF2

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Human: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

36kDa

Roth, A., (2008) Mol. Pharmacol. 73 (4), 1282-1289

Wet Ice

330

INSIG1

INSIG1

Rabbit

Insulin induced gene 1 EMBL EAL23728.1

NM_198336

TTWLFHKTRSNYRVFLKSPIVIESSKPPILRARKILEENLTVDYDKDYLF