Integrine beta3 (Vanaf 785) Antilichaam

The Itg-Beta3 gene encodes the beta subunit of the platelet membrane adhesive protein receptor complex Itg-Beta3 protein, which belongs to the Integrin class of cell adhesion molecule receptors that share a common heterotrimeric structure with Alpha and Beta subunits. It is a common Beta subunit of the platelet complex and of two other Integrins (Fibronectin and Vitronectin Receptors), which have distinct Alpha subunits. Itg-Beta3 has been implicated in a wide variety of functions, including platelet aggregation and thrombosis and implantation, placentation, angiogenesis, bone remodeling, and tumor progression. Glanzmann Thrombasthenia can result from defects in the genes for either the Itg-Alpha2B or the Itg-Beta3 subunit

3690

P05106

NP_000203.2

Human, Mouse, Rat

Integrin beta3 (Ab-785) antibody was raised against a peptide sequence around aa.783~787 (I-T-Y-R-G) derived from Human Integrin B3/ITGB3.

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

110 kDa

This antibody detects endogenous level of total Integrin β3 protein.

Western Blot: 1:500~1:1000

ITGB3

Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

Homo sapiens

Sujoy Bhattacharya, et al. (2006) Biochem J. August 1; 397 (Pt 3) : 437–447Courter DL, et al. (2005) J Biol Chem Apr 01; 280 (13) : 12145-12151Chandhoke SK, et al. (2004) J Cell Sci Mar 15; 117 (Pt 8) : 1431-1441

GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, CD61 antigen, ITB3, Platelet membrane glycoprotein IIIa

WB

47078292

Liquid