Interferon-a Receptor (fosfo Ser535/539) Antilichaam

Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon-alpha Receptor (IFNAR1) . Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.

3454

P17181

P17181

Human, Mouse, Rat, Bovine

IFNAR1 (Ser535/539) polyclonal antibody was raised against a synthetic phosphopeptide corresponding to amino acid residues surrounding the human Phospho-Ser535, 539 Type I Interferon-a Receptor Subunit 1 (IFNAR1) .

Unconjugated

Primary Antibodies

Signal Transduction, Phospho-Specific

Affinity Purified

Batch dependent

Phospho-Specific

Blue Ice

For long term storage –80˚ C is recommended, but shorter term storage at –20˚ C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.

110-130

Interferon a Receptor antibody is specific for IFNAR1 phosphorylated at Ser535,539.

Applications include Dot Blots (DB) and Western Blots (WB) . Suitability for Immunohistochemistry (IHC) has not yet been determined. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB.

IFNAR1

Interferon (alpha, beta and omega) receptor 1

Homo sapiens

Suresh Kumar, K.G., Tang, W., Ravindranath, A.K., Clark, W.A., Croze, E., Fuchs, S.Y., "SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon- receptor, " The EMBO Journal, 22 (2003), 5480-5490.

Kirkwood, J., "Cancer immunotherapy: the interferon- experience, " Semin. Oncol., 29 (2002) 18-26.

Biron, C.A., "Interferons alpha and beta as immune regulators-a new look, " Immunity, 14 (2001) 661-664.

Stark, G.R., Kerr, I.M., Williams, B.R., Silverman, R.H. and Schreiber, R.D. "How cells respond to interferons." Annu. Rev. Biochem., 67 (1998) 227-264.

WB, IHC

90110827

Liquid