IQCG Polyklonale Antilichaam, AbBy FluorTM 350 Vervoeging

IQCG is a 443 amino acid protein containing one IQ domain. Widely distributed in nature, the IQ domain forms an amphiphilic seven-turn -helix capable of binding calmodulin in a Ca2+-independent manner. The level of intracellular calcium is tightly regulated in all eukaryotic cells. A modest increase in this level can result in a myriad of physiological responses, most of which are mediated by calmodulin (CaM), the universal calcium sensor. In acute T-lymphoid/myeloid leukemia, IQCG forms a complex with Nup98, an O-linked glycoprotein and a component of the nuclear pore complex. NUP98-IQCG complex bind co-activators and/or co-repressors, which suggest a role in transcriptional regulation.Nup98-IQCG complex inhibits 32Dcl3 cell apoptosis induced by Arabinofuranosylcytosine (Ara-C) and partially blocks granulocyte differentiation induced by G-CSF. IQCG exists as two isoforms due to alternatively splicing events.

IQ domain containing protein G; IQ mot containing G; DKFZp434B227; FLJ11667; FLJ23571; FLJ37775; IQCG_HUMAN.

84223

Human

301-400/443

IQCG

AbBy Fluor™ 350

KLH conjugated synthetic peptide derived from human IQCG

WB, IF (IHC-P)

Purified by Protein A.

346nm/442nm

1µg/µl

WB (1:300-5000), IF (IHC-P) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

84223

Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Rabbit