IQSEC1 Antilichaam

ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1) . As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis (2,3) . IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy (4) .

9922

Q6DN90

NP_055684

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

IQSEC1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

IQSEC1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IQSEC1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

IQSEC1 antibody is human, mouse and rat reactive. At least four isoforms of IQSEC1 are known to exist. IQSEC1 antibody is predicted to not cross-react with IQSEC2.

IQSEC1

Cat. No. 17-208 - A-20 Cell Slide

IQ motif and Sec7 domain 1

Homo sapiens

Someya A, Sata M, Takeda K, et al. ARF-GEP (100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6. Proc. Natl. Acad. Sci. U.S.A. 2001; 98:2413-8.

Dunphy JL, Moravec R, Ly K, et al. The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins. Curr. Biol. 2006; 16:315-20.

Moravec R, Conger KK, D'Souza R, et al. BRAG2/GEP100/IQSec1 interacts with clathrin and regulates a5B1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5) . J. Biol. Chem. 2012; 287:31138-47.

Hu Z, Du J, Yang L, et al. GEP100/Arf6 is required for epidermal growth factor-induced ERK/Rac1 signaling and cell migration in human hepatoma HepG2 cells. PLoS One 2012; 7:e38777.

IQ motif and Sec7 domain 1, ADP-ribosylation factors guanine nucleotide-exchange protein 100, ARFGEP100, BRAG2, Brefeldin-resistant Arf-GEF 2 protein

ELISA, WB, ICC, IF

50582989

Liquid