IQSEC2 Antilichaam

ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. Similar to the related protein IQSEC1, IQSEC2 is a guanine nucleotide exchange protein for ARF1 and ARF6 that belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1,2) . IQSEC2 is a major component of the postsynaptic density (PSD) and colocalizes with PSD-95. It has been suggested to modulate the functions of the ARF proteins (1) . Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation (3) .

23096

Q5JU85

NP_001104595

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

IQSEC2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

IQSEC2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IQSEC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

IQSEC2 antibody is human, mouse and rat reactive. At least two isoforms of IQSEC2 are known to exist; this antibody will only detect the larger isoform. IQSEC2 antibody is predicted to not cross-react with IQSEC1.

IQSEC2

IQ motif and Sec7 domain 2

Homo sapiens

Murphy JA, Jensen ON, and Walikonis RS. BRAG1, a SEC7 domain-containing protein, is a component of the postsynaptic density of excitatory synapses. Brain Res. 2006; 1120:35-45.

Someya A, Sata M, Takeda K, et al. ARF-GEP (100), a guanine nucleotide-exchange protein for ADP-ribosy

Shoubridge C, Tarpey PS, Abidi F, et al. Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual ability. Nat. Genet. 2010; 42:486-8.

IQ motif and Sec7 domain 2, Brefeldin-resistant Arf-GEF 1 protein, BRAG1, MRX1

ELISA, WB, IHC-P

162138911

Liquid