IRAK4 (NM 001114182) Humaan Recombinant eiwit

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Purified recombinant protein of Human interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 1, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

IMD67; IPD1; IRAK-4; NY-REN-64; REN64

51135

Q9NWZ3, Q69FE3, B4E359

NM_001114182

12q12

E. coli

N-GST and C-His

Apoptosis, Neurotrophin signaling pathway, Toll-like receptor signaling pathway

Apoptosis, Neurotrophin signaling pathway, Toll-like receptor signaling pathway

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Druggable Genome, Protein Kinase

79.3 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

IRAK4

Human

NP_001107654

https://www.ncbi.nlm.nih.gov/gene/51135

https://www.uniprot.org/uniprot/Q9NWZ3

https://www.ncbi.nlm.nih.gov/nuccore/NM_001114182

https://www.ncbi.nlm.nih.gov/nuccore/NP_001107654