IRE1 Polyklonale Antilichaam, PE-Cy5 Vervoeging

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

IRE1; IRE1P; IRE1a; hIRE1p; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; Ire1-alpha; ERN1

2081

O75460

Cytoplasm, Cell membrane

Human, Rat

252-260/977

IRE1

PE-Cy5

KLH conjugated synthetic peptide derived from human IRE1a

WB, FCM

Purified by Protein A.

488nm/670nm

1µg/µl

WB (1:300-5000), FCM (1:20-100)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

2081

Mouse, Dog, Cow, Pig, Horse, Rabbit