IREB2 Antilichaam - middengebied: Biotine (ARP405009_P050-Biotine)

Iron-responsive element binding protein 2

ACO3, IRP2, IRP2AD, NDCAMA, IRE-BP2, IRE-BP 2

3658

P48200

NP_004127

Human, Mouse, Rat, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human IREB2

IREB2 binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. IREB2 binds to the IRE element in ferritin which results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

RBCK1; UBC; FAM96A; FAM96B; CIAO1; FBXL5; UBA2; TNPO1; CBS; TERT; USP53; APP; PSMA3; VHL; YBX1

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

105kDa

Zumbrennen, K.B., (2008) Biochim. Biophys. Acta 1783 (2), 246-252

Wet Ice

963

IREB2

IREB2

Rabbit

Iron-responsive element-binding protein 2

NM_004136

IQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEK