IRF3 Antilichaam

IRF3 Antibody: Interferons (IFN) s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF3 is present in an inactive form in the cytoplasm of most cells. Following viral infection, IRF3 can be activated by Iκ B kinase-ε and TANK-binding kinase 1 (TBK1), whereupon IRF3 translocates to the nucleus. IRF3 can also be activated by stimulation of toll-like receptor 3 (TLR3) by dsRNA. IRF3 exists as at least two distinct isoforms.

3661

Q14653

NP_001562

Human, Mouse

Unconjugated

Primary Antibodies

Chemokines & Cytokines, Homeostasis, Inflammasomes

IRF3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1225 - Ramos Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (86%), Pig: (79%)

IRF3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IRF3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

43, 47, 50 kDa

IgG

At least three isoforms of IRF3 are known to exist.

IRF3

Cat. No. 1405 - Mouse Kidney Tissue Lysate

Interferon regulatory factor 3

Homo sapiens

Malmgaard L. Induction and regulation of IFNs during viral infections. J. Interferon & Cyto. Res. 2004; 24:439-54

Au WC, Moore PA, Lowther W, et al. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. Proc. Natl. Acad. Sci. USA 1995; 92:11657-61.

Fitzgerald KA, McWhirter SM, Faia KL, et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 2003; 4:491-6.

Sharma S, Tenoever BR, Grandvaux N, et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 2003; 300:1148-51.

IRF3 Antibody: Interferon regulatory factor 3, IRF-3

ELISA, WB, IHC-P, IF

4504725

Liquid