IRF7 Antilichaam

IRF7 Antibody: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.

3665

Q92985

Q92985

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Innate Immunity, Cancer

IRF7 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

IRF7 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IRF7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

IRF7

Cat. No. 1406 - Mouse Spleen Tissue Lysate

Interferon regulatory factor 7

Homo sapiens

Malmgaard. J. Interferon & Cyto. Res. 2004; 24:439-54.

Sato et al. Immunity 2000; 13:539-48.

Fitzgerald et al. J. Exp. Med. 2003; 198:1043-55.

Honda et al. Proc. Natl. Acad. Sci. USA 2004; 101:15416-21.

IRF7 Antibody: IRF7A, IRF7B, IRF7C, IRF7H, IRF-7H, Interferon regulatory factor 7, IRF-7

ELISA, WB, IHC-P, IF

116242593

Liquid