IRGB10 (NT) Peptide

IRGB10 Antibody: IRGB10 is an inferno-inducible protein that is essential for the activation of DNA-sensing AIM2 inflammasome, and contributes to the activation of LPS-sensing caspase-11 and NLRP3 inflammasome. IRGB10 is part of a conserved signaling hub at the interface between cell-autonomous immunity and innate immune sensing pathways. IRGB10 targets cytoplasmic bacteria and compromises bacterial structural integrity. IRGB10 and LIGP2 act together to confer differential susceptibility against Chlamydia infection in mice.

631323

AGY29631

AGY29631

Peptides

200 ug/mL

PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide

Blue Ice

Store IRGB10 (NT) Peptide at -20˚ C, stable for one year.

IRGB10 (NT) Peptideis used for blocking the activity of theIRGB10 (NT) Antibody

Predicted gene 12250

Mus musculus

Man et al. Cell 2016; 167 (2) :382-396.e17

Bernstein-Hanley I et al. Proc Natl Acad Sci USA. 2006;103 (38) :14092-14097

Miyairi I et al. J Immunol 2007; 179 (3) :1814-1824

Coers J et al. J Immunol 2008; 180 (9) :6237-6245

IRGB10 Antibody: Immunity-related GTPase family member b10, Interferon-gamma-inducible p47 GTPase, Gm12250, OTTMUSG00000005723

Blocking

Mouse

551032829

Liquid