IRGB10 (Tent) Antilichaam

IRGB10 Antibody: IRGB10 is an inferno-inducible protein that is essential for the activation of DNA-sensing AIM2 inflammasome, and contributes to the activation of LPS-sensing caspase-11 and NLRP3 inflammasome. IRGB10 is part of a conserved signaling hub at the interface between cell-autonomous immunity and innate immune sensing pathways. IRGB10 targets cytoplasmic bacteria and compromises bacterial structural integrity. IRGB10 and LIGP2 act together to confer differential susceptibility against Chlamydia infection in mice.

631323

AGY29631

AGY29631

Mouse

9513

Unconjugated

Primary Antibodies

Signal Transduction, Inflammasomes

IRGB10 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1405 – Mouse Kidney Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat (100%), Hamster (85%)

IRGB10 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IRGB10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Mouse IRGB10 has 1 isoform (417aa, 47.2kD) .

IRGB10

Cat. No. 1419 – Mouse Skin Lysate

Cat. No. 1411 – Mouse Colon Lysate

Predicted gene 12250

Mus musculus

Man et al. Cell 2016; 167 (2) :382-396.e17

Bernstein-Hanley I et al. Proc Natl Acad Sci USA. 2006;103 (38) :14092-14097

Miyairi I et al. J Immunol 2007; 179 (3) :1814-1824

Coers J et al. J Immunol 2008; 180 (9) :6237-6245

IRGB10 Antibody: Immunity-related GTPase family member b10, Interferon-gamma-inducible p47 GTPase, Gm12250, OTTMUSG00000005723

ELISA, WB, IF

551032829

Liquid