IRS 1 (Ab 636) Antilichaam

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit

3667

P35568

NP_005535.1

Human, Mouse, Rat

IRS-1 (Ab-636) antibody was raised against a peptide sequence around aa.634~638 (P-M-S-P-K) derived from Human IRS-1.

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

180 kDa

This antibody detects endogenous level of total IRS-1 protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

IRS1

Insulin receptor substrate 1

Homo sapiens

Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8) : 4640-4645Tzatsos A, et al. (2006) Mol Cell Biol; 26 (1) : 63-76Kadowaki T, et al. (2000) J Clin Invest; 106 (4) : 459-465Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8) : 4640-4645Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97 (5) : 2355-2360

HIRS-1, BHLHB26, IRS-1, IRS1

WB, IHC, IF

5031805

Liquid