IRS 1 (fosfo Ser312) Antilichaam

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit

3667

P35568

NP_005535.1

Human, Mouse, Rat

IRS-1 (Phospho-Ser312) antibody was raised against a peptide sequence around phosphorylation site of serine 312 (A-T-S (p) -P-A) derived from Human IRS-1.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

180 kDa

This antibody detects endogenous levels of IRS-1 only when phosphorylated at serine 312.

Western Blot: 1:500~1:1000

IRS1

Insulin receptor substrate 1

Homo sapiens

Tzatsos A, et al. (2006) Mol Cell Biol; 26 (1) : 63-76Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8) : 4640-4645Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97 (5) : 2355-2360Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8) : 4640-4645

HIRS-1, OCT1, OTF1, HIRS-1, IRS1, Insulin receptor substrate 1

WB

5031805

Liquid