IRS 1 (fosfo Ser639) Antilichaam

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit

3667

P35568

NP_005535.1

Human, Mouse, Rat

IRS-1 (Phospho-Ser639) antibody was raised against a peptide sequence around phosphorylation site of serine 639 (P-K-S (p) -V-S) derived from Human IRS-1.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

180 kDa

This antibody detects endogenous level of IRS-1 only when phosphorylated at serine 639.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

IRS1

Insulin receptor substrate 1

Homo sapiens

Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8) : 4640-4645Tzatsos A, et al. (2006) Mol Cell Biol; 26 (1) : 63-76Steppan CM, et al. (2005) Mol Cell Biol; 25 (4) : 1569-1575Batty IH, et al. (2004) Biochem J; 379 (Pt 3) : 641-651

HIRS-1, NFKB3, IRS-1, IRS1

WB, IHC

5031805

Liquid