Isobutyramide
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Aldehyde Dehydrogenase Isobutyramide is an orally active liver alcohol dehydrogenase (LADH2) inhibitor. Isobutyramide inhibits ethanol metabolism and enhances differentiation-related gene expression, inducing cell cycle arrest and significantly reducing the growth rate of prostate cancer cells (LNCaP) . Isobutyramide is promising for research of advanced prostate cancer[1][2].
563-83-7
12352211
H302
Drug Metabolite
Metabolic Enzyme/Protease
Cancer
99.66
O=C(N)C(C)C
C4H9NO
87.12
H302
[1]Chadha VK, et al. Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism. J Med Chem. 1983 Jun;26 (6) :916-22.|[2]Gleave ME, et al. Butyrate analogue, isobutyramide, inhibits tumor growth and time to androgen-independent progression in the human prostate LNCaP tumor model. J Cell Biochem. 1998 Jun 1;69 (3) :271-81.
Room Temperature
Store at room temperature 3 years
http://file.medchemexpress.com/batch_PDF/HY-Y0943/Isobutyramide-SDS-MedChemExpress.pdf
Reference compound2
No Development Reported
Beschrijving
Aldehyde Dehydrogenase Isobutyramide is an orally active liver alcohol dehydrogenase (LADH2) inhibitor. Isobutyramide inhibits ethanol metabolism and enhances d
Specificaties
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1 Unit
MS 12-ch pipette, variable vol µme 2~20 µL
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1 Unit
MS Orbital Shaker with 30 x 30 cm platform and flat non-slip rubber mat
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