Isonanangenine B

Isonanangenine B (SF002-96-1) is a selective survivin inhibitor (IC50=1.6 µM) . Isonanangenine B blocks the binding of key transcription factors, such as Stat3 and NF-κB, to the survivin promoter. Isonanangenine B is promising for research of cancers[1][2].

1623153-14-9

SF002-96-1

12352005

Survivin

Apoptosis

Cancer-programmed cell death

Cancer

C[C@]12[C@@](C(C)(CC[C@H]2O)C)([H])[C@@H](C=C3[C@@]1(COC3=O)O)OC(CCCCC)=O

C21H32O6

380.48

[1]Lacey HJ, et al. Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis. Beilstein J Org Chem. 2019 Nov 5;15:2631-2643.|[2]Felix S, et al. SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expression. Beilstein J Org Chem. 2013 Dec 13;9:2866-76.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N12173/

Natural Products

No Development Reported