ISRIB
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM.1 Enhances spatial and fear-associated learning in mice and enhances cognitive function.1,2 Mechanism of action involves activation of eiF2β.3 Suppresses ER stress-induced inflammatory gene expression.4 Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production.5 Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.6
Unconjugated
White solid
-20°C
Beschrijving
ISRIB Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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