IT 066 (hydrochloride)

IT 066 hydrochloride is a Histamine H2 receptor antagonist. IT 066 hydrochloride possesses antioxidant activity and can protect rats against acute gastric mucosal injury induced by ischemia-reperfusion. IT 066 hydrochloride can also inhibit secretagogue-induced gastric acid secretion in rats and exert a long-acting anti-lesion effect on experimental gastric and duodenal lesions in rats. IT 066 hydrochloride is applicable for the research of gastrointestinal diseases[1][2].

126463-66-9

12352005

Histamine Receptor

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

COVID-19-immunoregulation

Inflammation/Immunology

O=C1C(C(N)=C1NC/C=C\COC2=NC=CC(CN3CCCCC3)=C2)=O.Cl

C19H25ClN4O3

392.88

[1]Naito Y, et al. Effect of a novel histamine H2 receptor antagonist, IT-066, on acute gastric injury induced by ischemia-reperfusion in rats, and its antioxidative properties. Eur J Pharmacol. 1995 Dec 27;294 (1) :47-54.|[2]Isobe Y, et al. Antisecretory and antilesional effect of a new histamine H2-receptor antagonist, IT-066, in rats. J Pharmacol Exp Ther. 1990 Dec;255 (3) :1078-82.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19105A/

Reference compound1

No Development Reported