ITCH (fosfo Tyr420) Antilichaam

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain.

83737

Q96J02

NP_001244066.1

Human, Mouse

ITCH (phospho Tyr420) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 420 (F-I-Y (p) -G-N) derived from Human ITCH .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

102 kDa

IgG

The antibody detects endogenous levels of ITCH only when phosphorylated at tyrosine 420.

ITCH

Itchy E3 ubiquitin protein ligase

Homo sapiens

Chen X., Genomics 73:238-241 (2001) .

Deloukas P., Nature 414:865-871 (2001) .

Wood J.D., Mol. Cell. Neurosci. 11:149-160 (1998) .

AIF4, AIP4, NAPP1

IHC

380420335

Liquid