ITGB3BP Antilichaam

This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.

23421

Q13352

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human ITGB3BP (NP_055103.3) .

Unconjugated

Primary Antibodies

Apoptosis, Cell Cycle, Signal Transduction

Affinity purification

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

IgG

IHC: 1:50 - 1:200

ITGB3BP

Integrin beta 3 binding protein (beta3-endonexin)

Homo sapiens

ITGB3BP, CENP-R, CENPR, HSU37139, NRIF3, TAP20

IHC

Liquid