ITGB4 Antilichaam

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

3691

P16144

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 28-310 of human ITGB4 (NP_000204.3) .

Unconjugated

Primary Antibodies

Cell Cycle, Immunology, Signal Transduction

Affinity purification

A431

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 202kDa

IgG

ITGB4

BxPC-3

Mouse pancreas

Integrin, beta 4

Homo sapiens

ITGB4, CD104, Integrin beta-4, Integrin Beta 4, gp150, CD104 antigen, Integrin beta-4 subunit, Integrin, beta 4

WB, IHC

Liquid