ITM2C Antilichaam - middengebied: HRP (ARP44631_P050-HRP)

Integral membrane protein 2C

E25, BRI3, E25C, ITM3, BRICD2C

81618

Q9NQX7

NP_112188

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

ITM2C is a negative regulator of beta amyloid peptide production. ITM2C may inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor.ITM2C may play a role in TNF-induced cell death and neuronal differentiation.

UBC; Dlg4; RYK; BACE1; RNF7; STT3A; MTNR1B; FURIN

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Zebrafish: 91%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

30kDa

Wet Ice

267

ITM2C

ITM2C

Rabbit

Integral membrane protein 2C

NM_030926

EDSLSSQVRTQMELEEDVKIYLDENYERINVPVPQFGGGDPADIIHDFQR