Itopride-d6

Itopride-d6 (HSR803-d6 (free base) ) is deuterium labeled Itopride. Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD) [1].

1346746-82-4

HSR803-d6 (free base)

12352005

Bacterial; Cholinesterase (ChE) ; Dopamine Receptor; Isotope-Labeled Compounds

Anti-infection; GPCR/G Protein; Neuronal Signaling; Others

COVID-19-immunoregulation

Others

[2H]C([2H])([2H])N(C([2H])([2H])[2H])CCOC(C=C1)=CC=C1CNC(C2=CC(OC)=C(C=C2)OC)=O

C20H20D6N2O4

364.47

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Iwanaga Y, et al. A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine. Gastroenterology. 1990 Aug;99 (2) :401-8.|[3]Kim YS, et al. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study. World J Gastroenterol. 2005 Jul 21;11 (27) :4210-4.|[4]Hyun Chul Lim, et al. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Yonsei Med J. 2008 Jun 30;49 (3) :472-8.|[5]Kenjiro Matsumoto, et al. Validation of 13 C-Acetic Acid Breath Test by Measuring Effects of Loperamide, Morphine, Mosapride, and Itopride on Gastric Emptying in Mice. Biol Pharm Bull. 2008 Oct;31 (10) :1917-22.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0732AS/

Isotope-Labeled Compounds

No Development Reported