Ivermectine

70288-86-7

MK-933

C16261-10mM/1mL

Chloride Channel

Transmembrane Transporters

CCC (C) C1C (CCC2 (O1) CC3CC (O2) CC=C (C (C (C=CC=C4COC5C4 (C (C=C (C5O) C) C (=O) O3) O) C) OC6CC (C (C (O6) C) OC7CC (C (C (O7) C) O) OC) OC) C) C

C48H74O14

Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs) . Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.

2 years -80 in solvent