JAG1 Antilichaam

The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate decisions (1) . Ligands for Notch include JAG1, JAG2 and Delta. JAG1 is one of the DSL (Delta, Serrate, Lag2) transmembrane proteins that can activate Notch. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis (1,2) . JAG1 is widely expressed in adult and fetal tissues and the mutation of the JAG1 gene is associated with Familial Tetrology of Fallot (3) . JAG1 expression is associated with prostate cancer metastasis and is up-regulated in cervical squamous cell carcinoma (4,5) .

182

P78504

NP_000205

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Stem Cell

JAG1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

JAG1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

JAG1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

JAG1 antibody is human, mouse and rat reactive. At least two isoforms of JAG1 are known to exist; this antibody will detect both isoforms.

JAG1

Cat. No. 10-901 - Human Spleen Tissue Slide

Jagged 1

Homo sapiens

Lai EC. Notch signaling: control of cell communication and cell fate. Development 2004; 131:965-73.

Milner LA, Kopan R, Martin DI, et al. A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors. Blood1994; 83:2057-62.

Guida V, Chiappe F, Ferese R, et al. Novel and recurrent JAG1 mutations in patients with tetralogy of Fallot. Clin. Genet. 2011; 80:591-4.

Santagata S, Demichelis F, Riva A, et al. JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res. 2004; 64:6854-7.

Jagged 1, AGS, AHD, AWS, CD339, HJ1, JAGL1

ELISA, WB, IHC-P, IF

4557679

Liquid