JAGN1 Antilichaam

JAGN1 is the human ortholog of a gene originally identified in Drosophila melanogaster. It is a transmembrane protein that functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Individuals with mutations in the JAGN1 gene causes aberrant myeloid cell homeostasis and severe congenital neutropenia (SCN) (1) . JAGN1-mutant granulocytes are characterized by ultrastructural defects, aberrant N-glycosylation of multiple proteins, and increased apoptosis (1) . Mice lacking this gene could not mount and efficient neutrophil-dependent immune response to a human fungal pathogen (2) .

84522

Q8N5M9

NP_115881

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell, Immunology

JAGN1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1411 - Mouse Colon Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (95%)

JAGN1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

JAGN1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

JAGN1 antibody is human, mouse and rat reactive. At least four isoforms of JAGN1 are known to exist; this antibody will detect all but isoform 2.

JAGN1

Jagunal homolog 1

Homo sapiens

Boztug K, Jarvinen PM, Salzer E, et al. JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia. Nat. Genet. 2014; 46:1021-7.

Wirnsberger G, Zwolanek F, Stadlmann J, et al. Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense. Nat. Genet. 2014; 46:1028-33.

Jagunal homolog 1

ELISA, WB, IHC-P

190014601

Liquid