JAK2 Antilichaam

JAK2 is a member of the JAK family of kinases that also include JAK1, JAK3, and TYK2 (1,2) . JAK kinases are activated following tyrosine phosphorylation of cytokine receptors after ligand binding. JAK2 activation promotes the recruitment and phosphorylation of STAT3 and STAT5. These transcription factors then translocate to the nucleus where they bind specific DNA promoter sequences resulting in the transcription of genes that regulate cell proliferation, differentiation, and apoptosis (3) . Mice with a disrupted JAK2 gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis (4) .

3717

O60674

NP_004963

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell, Apoptosis

JAK2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1212 - 3T3 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (100%), Chicken: (82%)

JAK2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

JAK2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

JAK2 antibody is human, mouse and rat reactive. JAK2 antibody is predicted to not cross-react with other members of the JAK family of proteins.

JAK2

Janus kinase 2

Homo sapiens

Wilks AF, Harpur AG, Kurban RR, et al. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell Biol. 1991; 11:2057-66.

Quintas-Cardama A and Verstovsek S. Molecular pathways: JAK/STAT pathway: mutations, inhibitors, and resistance. Clin. Can. Res. 2013; 19:1933-40.

Levine RL, Pardanani A, Tefferi A, et al. Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders. Nat. Rev. Cancer 2007; 7:673-83.

Neubauer H, Cumano A, Muller M, et al. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 1998; 93:397-409.

Janus kinase 2, JTK10, THCYT3

ELISA, WB, IHC-P

4826776

Liquid