JAK3 Antilichaam - middengebied: Biotine (ARP54306 P050-Biotine)

Janus kinase 3

JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMAN

3718

P52333

NP_000206

Human, Mouse, Rat, Cow, Dog, Horse, Pig

The immunogen is a synthetic peptide directed towards the middle region of human JAK3

JAK3 is a member of the Janus kinase (JAK) family of tyrosine kinases, which is involved in cytokine receptor-mediated intracellular signal transduction. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease) .The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease) . Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Socs5; KIT; IL7R; TYK2; STAT6; STAT3; JAK2; JAK1; IL4R; GTF2B; ERBB3; CDK1; CD81; APOA1; UBC; SOCS3; UHRF2; STAT5A; IKBKG; ALK; SH2B2; TIAF1; INPP5D; PTPN2; STAM2; PRMT5; SOCS1; KHDRBS1; STAM; PTK2B; IRS2; SHB; JAK3; IL2RG; VIL1; FES; CD247; PTPN6; PIK3R1

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

125kDa

Cheng, H., (2008) Mol. Cell. Biol. 28 (7), 2271-2282

Wet Ice

1124

JAK3

JAK3

Rabbit

Tyrosine-protein kinase JAK3

NM_000215

KLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELF