JAKMIP1 Antilichaam

JAKMIP1 Antibody: JAKMIP1, also known as Marlin-1, is a highly-conserved vertebrate-specific microtubule-associated protein that plays a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. JAKMIP1 is expressed predominantly in neuronal and lymphoid cells and colocalizes with microtubules. Multiple isoforms of JAKMIP1 are known to exist: isoforms 1 and 5 are also expressed in liver, lung and skeletal muscle, while isoforms 2-4 are specifically expressed in brain and retina. JAKMIP1 participates in polarized secretion in lymphocytes and it has been suggested to be a novel effector memory gene restraining T cell-mediated cytotoxicity. Dysregulation of JAKMIP1 gene expression is associated with genetic conditions linked to autism in humans.

152789

Q96N16

NP_653321

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

JAKMIP1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

JAKMIP1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

JAKMIP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 69 kDa

IgG

Multiple isoforms of JAKMIP1 are known to exist. JAKMIP1 antibody is predicted to not cross-react with JAKMIP2.

JAKMIP1

Janus kinase and microtubule interacting protein 1

Homo sapiens

Costa V, Conte I, Ziviello C, et al. Identification and expression analysis of novel Jakmip1 transcripts. Gene 2007; 402:1-8.

Vidal RL, Fuentes P, Valenzuela JI, et al. RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons. Mol. Cell Neurosci. 2012; epub.

Libri V, Schulte D, Van Stijn A et al. Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes. J. Immunol. 2008; 181:5847-56

Bill BR, Geschwind DH. Genetic advances in autism: heterogeneity and convergence on shared pathways. Curr. Opin. Genet. Dev. 2009; 19:271-8.

JAKMIP1 Antibody: JAMIP1, MARLIN1, Gababrbp, GABABRBP, JAMIP1, Janus kinase and microtubule-interacting protein 1, GABA-B receptor-binding protein, Marlin-1

ELISA, WB

21389505

Liquid